Dr. Wu's lab focuses on post-transcriptional gene regulation and its involvement in human pathogenesis, especially neurodegeneration and tumor pathogenesis.
Her group is investigating the cellular and molecular mechanisms controlling cancer metastasis.
Dr Wu has identified a family of secreted proteins, Slit, that regulates neuronal migration, modulates leukocyte chemotaxis and suppresses cancer cell migration. The observation that Slit is frequently inactivated in a range of tumors indicates a role of Slit gene in tumor suppression. Her team has begun to examine the role of Slit signaling in brain tumor and is developing new therapeutic approaches to treating brain tumor based on restricting or suppressing brain tumor invasion.
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